CPSR:

Database	                What it contributes
Genomics England PanelApp	Restricts the search to genes actually implicated in cancer predisposition, tiered by confidence (diagnostic-grade vs. low-confidence)
ClinVar	                    Existing expert/lab pathogenicity classifications for known variants
gnomAD	                    Population allele frequency — a variant common in the general population is very unlikely to be a rare disease-causing allele
CIViC	                    Clinically curated germline biomarkers
NHGRI-EBI GWAS Catalog	    Low-risk/susceptibility alleles from genome-wide association studies