```
T|stop_gained|HIGH|BRCA2|ENSG00000139618|Transcript|ENST00000380152|protein_coding|11/27||ENST00000380152.8:c.4777G>T|ENSP00000369497.3:p.Glu1593Ter|4976/11954|4777/10257|1593/3418|E/*|Gaa/Taa|COSV66463787|...
```

Field	             Value	            Meaning
Allele	             T	                The alternate allele being annotated
Consequence	         stop_gained	    A premature stop codon is introduced
IMPACT	             HIGH	            VEP's coarse severity bucket (HIGH/MODERATE/LOW/MODIFIER)
SYMBOL	             BRCA2	            Gene symbol
Feature	             ENST00000380152	The specific Ensembl transcript this consequence applies to
BIOTYPE	             protein_coding	    This transcript is a normal coding transcript
EXON	             11/27	            The variant falls in exon 11 of 27
HGVSc	             c.4777G>T	        The coding-DNA-level change
HGVSp	             p.Glu1593Ter	    The predicted protein change — glutamate 1593 becomes a stop codon
Existing_variation	 COSV66463787	    This exact variant is already catalogued in COSMIC