Name	Description	pvalue	qvalue	phenotype	genes
HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY	HALLMARK_ESTROGEN_RESPONSE_EARLY%MSigdbHallmark%HALLMARK_ESTROGEN_RESPONSE_EARLY	4.73761893964086e-08	4.73761893964086e-08	-1	DHRS2,SLC7A2,CLDN7,ANXA9,BCL2,TPD52L1,LAD1,MUC1,TJP3,SULT2B1,TFF1,TFF3,ELF1,MINDY1,OVOL2,FRK,ELF3,RHOBTB3,TMPRSS3,SCNN1A,SLC24A3,SLC37A1,SLC39A6,KRT19,ELOVL5,MREG,TOB1,MSMB,DEPTOR,TTC39A,SLC27A2,RETREG1,MICB,MLPH
CELL-CELL ADHESION%GOBP%GO:0098609	cell-cell adhesion	7.1723086724809e-07	7.1723086724809e-07	-1	CDH1,NCAM2,PKP1,CDH12,ALCAM,NECTIN4,CLDN7,CLSTN2,TENM1,EPCAM,NPNT,ANXA9,NRXN3,TACSTD2,CLDN4,DSCAM,MPZL2,TJP3,CSTA,IGSF9,SELL,CTNND2,CDH18,PLEKHA7,SLC39A8,FLRT3,XG,IGDCC3,ADGRV1,CLDN1,PCDHB5,LRG1,HMCN1,PERP,AMIGO2,PLPP3,JUP,ITGB6,NRCAM,ITGA10,DLG3,CDH13,PCDH8,IGSF5,CD24,ASTN2,WNT7B,CDH3,CTNND1,SDK1,GOLPH3,NECTIN1,TJP2,ROBO1,PCDHB13
CELL JUNCTION ORGANIZATION%GOBP%GO:0034330	cell junction organization	2.58635386138274e-06	2.58635386138274e-06	-1	CDH1,GRHL2,PKP1,ANK3,CDH12,CLDN7,TENM1,NRXN3,MARVELD3,SLITRK6,DSCAM,TJP3,TGFB3,CTNND2,POF1B,DRD1,MPP7,CDH18,PLEKHA7,MARVELD2,CD9,FLRT3,TESK2,ZNF703,CLDN1,CRB3,PCDHB5,DRD2,SORBS1,MTSS1,SRCIN1,JUP,ILDR1,NRCAM,GABRA3,AKAP5,EPHB3,CDH13,PPFIBP2,APBB2,PRRT1,SLC39A9,OCLN,WNT7B,CDH3,SDK1,PTPRK,TJP2,PATJ,PCDHB13,SYN3
CELL-CELL JUNCTION ORGANIZATION%GOBP%GO:0045216	cell-cell junction organization	7.24186982201557e-06	7.24186982201557e-06	-1	CDH1,GRHL2,PKP1,CDH12,CLDN7,MARVELD3,TJP3,TGFB3,POF1B,MPP7,CDH18,PLEKHA7,MARVELD2,CD9,ZNF703,CLDN1,CRB3,MTSS1,JUP,ILDR1,CDH13,SLC39A9,OCLN,CDH3,TJP2,PATJ
HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE%MSigdbHallmark%HALLMARK_ESTROGEN_RESPONSE_LATE	1.81967771996665e-05	1.81967771996665e-05	-1	DHRS2,BATF,ANXA9,BCL2,TPD52L1,TJP3,SULT2B1,TFF1,ST14,TFF3,MAPK13,EMP2,CD9,OVOL2,FRK,PRLR,PERP,PCP4,TMPRSS3,SCNN1A,SLC24A3,KRT19,ELOVL5,TOB1,TH,SLC27A2,LLGL2,MICB,SERPINA3
CATECHOLAMINE METABOLIC PROCESS%GOBP%GO:0006584	catecholamine metabolic process	1.85828106027634e-05	1.85828106027634e-05	-1	MAOB,GATA3,DRD1,MAOA,DRD2,RNF180,SNCAIP,TH,ATP7A,DDC,SULT1A1
CATECHOL-CONTAINING COMPOUND METABOLIC PROCESS%GOBP%GO:0009712	catechol-containing compound metabolic process	1.85828106027634e-05	1.85828106027634e-05	-1	MAOB,GATA3,DRD1,MAOA,DRD2,RNF180,SNCAIP,TH,ATP7A,DDC,SULT1A1
CELL JUNCTION ASSEMBLY%GOBP%GO:0034329	cell junction assembly	2.54386855252252e-05	2.54386855252252e-05	-1	CDH1,GRHL2,PKP1,CDH12,NRXN3,MARVELD3,SLITRK6,DSCAM,POF1B,DRD1,MPP7,CDH18,MARVELD2,CD9,FLRT3,TESK2,ZNF703,CLDN1,PCDHB5,DRD2,SORBS1,JUP,ILDR1,NRCAM,GABRA3,AKAP5,CDH13,SLC39A9,OCLN,CDH3,SDK1,PTPRK,PATJ,PCDHB13
EPIDERMIS DEVELOPMENT%GOBP%GO:0008544	epidermis development	2.54386855252252e-05	2.54386855252252e-05	-1	GRHL2,CLDN4,OVOL1,CSTA,MYO6,CALML5,ST14,SPINT1,POU2F3,GRHL3,GRHL1,KDF1,ABCA12,CLDN1,OVOL2,CRABP2,TP63,SPINK5,EXPH5,ASAH1,EDA2R,AKR1C3,HLA-DRB1,ATP7A,CDH3,ZNF750,FGFR2,STS,KRT10,PITX2
AMINE METABOLIC PROCESS%GOBP%GO:0009308	amine metabolic process	0.000158601763204293	0.000158601763204293	-1	MAOB,GATA3,DRD1,MAOA,DRD2,RNF180,AOC1,SNCAIP,TH,ATP7A,SLC44A2,DDC,SULT1A1,ALDH7A1,SULT1A2
CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012	Cadherin signaling pathway	0.000188864559885767	0.000188864559885767	-1	CDH1,CDH12,CTNND2,CDH18,LEF1,FZD4,PCDHB5,PCDHA13,PCDHA3,PCDHA6,PCDH19,PCDH1,CDH13,PCDH8,PCDHGA3,PCDHA1,WNT7B,PCDHA9,CDH3,PCDHGA8,CTNND1,PCDHA12,PCDHB13
PHENOL-CONTAINING COMPOUND METABOLIC PROCESS%GOBP%GO:0018958	phenol-containing compound metabolic process	0.000195885264677457	0.000195885264677457	-1	MAOB,GATA3,DRD1,TPO,MAOA,DRD2,RNF180,SNCAIP,TH,ATP7A,DDC,DIO2,SULT1A1,SULT1A2
DOPAMINE METABOLIC PROCESS%GOBP%GO:0042417	dopamine metabolic process	0.000195885264677457	0.000195885264677457	-1	MAOB,DRD1,MAOA,DRD2,SNCAIP,TH,ATP7A,DDC,SULT1A1
CIRCULATORY SYSTEM PROCESS%GOBP%GO:0003013	circulatory system process	0.000247641690079111	0.000247641690079111	-1	SLC7A2,KCNJ3,SLC7A8,CACNA1D,TJP3,SGCG,ADCY6,SCN2A,TNNI1,ZG16B,ABCG2,SLC1A2,ATP2A3,ANGPT1,KCNE4,CD36,CAMK2D,DMD,FGF12,RYR2,ATP8A1,DRD2,ID2,SCNN1A,DDAH1,SLC24A3,ANK2,ABCC5,SLC38A1,OCLN,DOCK4,EDN1,TNNT2,SLC12A2,GAB1,TJP2,P2RX4,SLC15A2,SLC13A3,SLC38A3,SCNN1G,FLVCR2
CELL-CELL JUNCTION ASSEMBLY%GOBP%GO:0007043	cell-cell junction assembly	0.000290923985643275	0.000290923985643275	-1	CDH1,GRHL2,PKP1,CDH12,MARVELD3,POF1B,MPP7,CDH18,MARVELD2,CD9,ZNF703,CLDN1,JUP,ILDR1,CDH13,SLC39A9,OCLN,CDH3,PATJ
ANATOMICAL STRUCTURE HOMEOSTASIS%GOBP%GO:0060249	anatomical structure homeostasis	0.000305589737499741	0.000305589737499741	-1	ANK3,FREM2,TJP3,TFF1,ADCY6,TFF3,ACP5,ANGPT1,SLC39A8,FREM1,ADGRV1,CLDN1,DMD,GCNT2,PERP,ILDR1,APBB2,OCLN,CDH3,SLC12A2,TJP2,P2RX4,SERPINA3
TISSUE HOMEOSTASIS%GOBP%GO:0001894	tissue homeostasis	0.000305589737499741	0.000305589737499741	-1	ANK3,FREM2,TJP3,TFF1,ADCY6,TFF3,ACP5,ANGPT1,SLC39A8,FREM1,ADGRV1,CLDN1,DMD,GCNT2,PERP,ILDR1,APBB2,OCLN,CDH3,SLC12A2,TJP2,P2RX4,SERPINA3
EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0030855	epithelial cell differentiation	0.000453508119971247	0.000453508119971247	-1	RAB25,GRHL2,PKP1,EHF,IRF6,AKR1C2,TJP3,OVOL1,CSTA,POF1B,MYO6,GATA3,ST14,MARVELD2,POU2F3,ABCA12,CDK6,UPK2,ZNF703,OVOL2,BMP4,SPINK5,KRT20,ID2,MTSS1,KRT12,SIPA1L3,KRT23,EXPH5,ASAH1,KRT19,AKR1C3,CD24,KRT39,WNT7B,CDH3,FGFR2,DLX3,TJP2,SOX4,KRT10,PITX2
BIOGENIC AMINE METABOLIC PROCESS%GOBP%GO:0006576	biogenic amine metabolic process	0.000901276003449825	0.000901276003449825	-1	MAOB,GATA3,DRD1,MAOA,DRD2,RNF180,AOC1,SNCAIP,TH,ATP7A,DDC,SULT1A1
TIGHT JUNCTION ORGANIZATION%GOBP%GO:0120193	tight junction organization	0.00102647255136635	0.00102647255136635	-1	GRHL2,MARVELD3,POF1B,MPP7,MARVELD2,CLDN1,CRB3,ILDR1,SLC39A9,OCLN,PATJ
FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868	Fatty acid metabolism	0.00152167768674839	0.00152167768674839	-1	CYP2J2,ALOX15,CYP4B1,CYP4F8,CYP4F22,CYP4F3,CYP4A22,THRSP,ACOXL,MID1IP1,ACOT4,ELOVL5,MCEE,AKR1C3,ACSL3,MMAA,HSD17B4,DECR1,ACOT13,CROT,SLC27A2,ACOT11,THEM5,ACSL1
FATTY ACIDS%REACTOME%R-HSA-211935.6	Fatty acids	0.00200688665648811	0.00200688665648811	-1	CYP2J2,CYP4B1,CYP4F8,CYP4F22,CYP4F3,CYP4F12,CYP4A22
CELL MORPHOGENESIS%GOBP%GO:0000902	cell morphogenesis	0.00313031984032212	0.00313031984032212	-1	RAB25,CDH1,GRHL2,ANK3,CDH12,ALCAM,TENM1,NRXN3,NOTCH3,SLITRK6,DSCAM,UNC5C,IGSF9,CTNND2,POF1B,SEMA5A,EPHA3,CDH18,TRIM46,FLRT3,MAP6,NTN4,SHROOM3,SEMA4A,DRD2,SIPA1L3,NRCAM,SEMA3F,EPHB3,CLU,POTEI,CDH13,RPS6KA5,POTEF,ATP7A,NCAM1,MPIG6B,EPHA6,WNT7B,CDH3,POTEE,FGFR2,PACSIN1,ROBO1
SMALL MOLECULE CATABOLIC PROCESS%GOBP%GO:0044282	small molecule catabolic process	0.00320220350854667	0.00320220350854667	-1	KYNU,QPRT,FUT9,CYP4F8,HGD,PRODH,CYP4F3,CYP4F12,ACSS1,OXCT1,ALDH1L1,CSAD,DDAH1,ACOXL,NPL,ACOT4,MCEE,ALDH5A1,FUT8,MAT1A,AKR1C3,HSD17B4,ALDH6A1,MCCC2,DECR1,SULT1A1,CROT,SLC27A2,CYP27B1,HMGCLL1,NUDT4,HSD17B6,ALDH7A1,SULT1A2
EICOSANOIDS%REACTOME%R-HSA-211979.3	Eicosanoids	0.0033170603290098	0.0033170603290098	-1	CYP4B1,CYP4F8,CYP4F22,CYP4F3,CYP4F12,CYP4A22
TIGHT JUNCTION ASSEMBLY%GOBP%GO:0120192	tight junction assembly	0.00347868643936947	0.00347868643936947	-1	GRHL2,MARVELD3,POF1B,MPP7,MARVELD2,CLDN1,ILDR1,SLC39A9,OCLN,PATJ
VASCULAR PROCESS IN CIRCULATORY SYSTEM%GOBP%GO:0003018	vascular process in circulatory system	0.00497293978712753	0.00497293978712753	-1	SLC7A2,SLC7A8,TJP3,ADCY6,ZG16B,ABCG2,SLC1A2,ATP2A3,ANGPT1,CD36,ATP8A1,DDAH1,SLC24A3,ABCC5,SLC38A1,OCLN,DOCK4,EDN1,SLC12A2,GAB1,TJP2,SLC15A2,SLC13A3,SLC38A3,FLVCR2
VASCULAR TRANSPORT%GOBP%GO:0010232	vascular transport	0.00676720950841204	0.00676720950841204	-1	SLC7A2,SLC7A8,ABCG2,SLC1A2,ATP2A3,CD36,ATP8A1,SLC24A3,ABCC5,SLC38A1,SLC12A2,SLC15A2,SLC13A3,SLC38A3,FLVCR2
SPHINGOLIPID METABOLIC PROCESS%GOBP%GO:0006665	sphingolipid metabolic process	0.00676720950841204	0.00676720950841204	-1	ALDH3B2,FUT9,SPTSSB,FUT3,ABCG2,CYP4F22,SMPD3,ABCA12,DEGS2,PPM1L,PLPP3,ST8SIA6,ASAH1,ELOVL5,SPTSSA,GALC,CERS6,LARGE1,ACER2,SGPP1
FATTY ACID DERIVATIVE METABOLIC PROCESS%GOBP%GO:1901568	fatty acid derivative metabolic process	0.00676720950841204	0.00676720950841204	-1	ALOX15,ACSS3,GGT6,CYP4F12,OXCT1,FAR2,ELOVL5,ACSL3,HSD17B4,HMGCS2,SLC27A2,HMGCLL1,THEM5,ACSL1
TRANSPORT ACROSS BLOOD-BRAIN BARRIER%GOBP%GO:0150104	transport across blood-brain barrier	0.00676720950841204	0.00676720950841204	-1	SLC7A2,SLC7A8,ABCG2,SLC1A2,ATP2A3,CD36,ATP8A1,SLC24A3,ABCC5,SLC38A1,SLC12A2,SLC15A2,SLC13A3,SLC38A3,FLVCR2
POSITIVE REGULATION OF BLOOD-BRAIN BARRIER PERMEABILITY%GOBP%GO:1905605	positive regulation of blood-brain barrier permeability	0.00714988006791841	0.00714988006791841	-1	TJP3,ANGPT1,OCLN,TJP2
POSITIVE REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010811	positive regulation of cell-substrate adhesion	0.00929686473427506	0.00929686473427506	-1	AGR2,ALOX15,NPNT,NEDD9,EMP2,LEF1,CDK6,CD36,CCL28,EPHA1,PLPP3,JUP,CDH13,CCR7,CARMIL1
LIPID CATABOLIC PROCESS%GOBP%GO:0016042	lipid catabolic process	0.010168005776524	0.010168005776524	-1	ALDH3B2,PLA2G4F,LIPH,SMPD3,SMPDL3B,MGST2,CYP4F12,OXCT1,PLPP3,ACOXL,ASAH1,GDPD1,MCEE,AKR1C3,GALC,GDPD3,HSD17B4,DECR1,CROT,SLC27A2,CYP27B1,SCARB2,PLA2G6,ACER2,STS,SGPP1,HSD17B6
MAMMARY GLAND DEVELOPMENT%GOBP%GO:0030879	mammary gland development	0.0110931388674205	0.0110931388674205	-1	IRF6,TGFB3,ZNF703,PRLR,PERP,ELF3,ID2,WNT7B,FGFR2
SEROTONIN METABOLIC PROCESS%GOBP%GO:0042428	serotonin metabolic process	0.0130043097653166	0.0130043097653166	-1	MAOB,MAOA,RNF180,ATP7A,DDC
BICELLULAR TIGHT JUNCTION ASSEMBLY%GOBP%GO:0070830	bicellular tight junction assembly	0.0130043097653166	0.0130043097653166	-1	GRHL2,MARVELD3,POF1B,MPP7,MARVELD2,CLDN1,SLC39A9,OCLN
SPHINGOID METABOLIC PROCESS%GOBP%GO:0046519	sphingoid metabolic process	0.0133263528978493	0.0133263528978493	-1	SPTSSB,DEGS2,PLPP3,ASAH1,SPTSSA,ACER2,SGPP1
BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859	Biological oxidations	0.0138050175195339	0.0138050175195339	-1	CYP2J2,CYP4B1,MAOB,CYP4F8,GGT6,CYP4F22,CMBL,CYP4F3,MGST1,MGST2,CYP4F12,MAOA,ACSS1,CYP4A22,UGT2B15,AOC1,ALDH3A1,MAT1A,AHR,SULT1A1,GGCT,CYP27B1,SLC35D1,MAT2A,SULT1A2
POSITIVE REGULATION OF CELL-MATRIX ADHESION%GOBP%GO:0001954	positive regulation of cell-matrix adhesion	0.0157200869535164	0.0157200869535164	-1	EMP2,LEF1,CDK6,CD36,CCL28,EPHA1,PLPP3,JUP,CDH13,CCR7
NEGATIVE REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905331	negative regulation of morphogenesis of an epithelium	0.0157200869535164	0.0157200869535164	-1	TACSTD2,BMP4,SULF1,CTNND1
AMINOPHOSPHOLIPID TRANSPORT%GOBP%GO:0015917	aminophospholipid transport	0.0157200869535164	0.0157200869535164	-1	TMEM30B,ATP8A2,ATP8A1,SCARB2
7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260910%WP5064%HOMO SAPIENS	7 oxo C and 7 beta HC pathways	0.0158388545904029	0.0158388545904029	-1	HSD11B2,DBP,ACOT4,ACOT13,SLC27A2,ACOT11,THEM5
INDOLE-CONTAINING COMPOUND METABOLIC PROCESS%GOBP%GO:0042430	indole-containing compound metabolic process	0.0158388545904029	0.0158388545904029	-1	KYNU,QPRT,MAOB,MAOA,RNF180,ATP7A,DDC
HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197	Hydroxycarboxylic acid-binding receptors	0.0214005721004835	0.0214005721004835	-1	HCAR1,HCAR2,HCAR3
AXONOGENESIS%GOBP%GO:0007409	axonogenesis	0.0231905461967478	0.0231905461967478	-1	ANK3,ALCAM,TENM1,NRXN3,NOTCH3,SLITRK6,DSCAM,UNC5C,IGSF9,SEMA5A,EPHA3,TRIM46,NTN4,SEMA4A,DRD2,NRCAM,SEMA3F,EPHB3,POTEI,RPS6KA5,POTEF,NCAM1,EPHA6,WNT7B,POTEE,FGFR2,ROBO1
CARBOXYLIC ACID TRANSPORT%GOBP%GO:0046942	carboxylic acid transport	0.0244804896226993	0.0244804896226993	-1	SLC7A2,SLC7A8,ABCG2,SLC1A2,SLC44A5,CD36,ABCB4,CRABP2,DRD2,THRSP,SLC16A8,ABCC5,ACSL3,SLC38A1,SLC44A2,RBP1,SLC27A2,LLGL2,ABCC6,SLC13A3,SLC17A5,SLC38A3,ABCC11,CRABP1,ACSL1,SLC16A14
ORGANIC ACID TRANSPORT%GOBP%GO:0015849	organic acid transport	0.0244804896226993	0.0244804896226993	-1	SLC7A2,SLC7A8,ABCG2,SLC1A2,SLC44A5,CD36,ABCB4,CRABP2,DRD2,THRSP,SLC16A8,ABCC5,ACSL3,SLC38A1,SLC44A2,RBP1,SLC27A2,LLGL2,ABCC6,SLC13A3,SLC17A5,SLC38A3,ABCC11,CRABP1,ACSL1,SLC16A14
PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945	Phase I - Functionalization of compounds	0.024812843215048	0.024812843215048	-1	CYP2J2,CYP4B1,MAOB,CYP4F8,CYP4F22,CMBL,CYP4F3,CYP4F12,MAOA,ACSS1,CYP4A22,AOC1,ALDH3A1,AHR,CYP27B1
MAMMARY GLAND EPITHELIUM DEVELOPMENT%GOBP%GO:0061180	mammary gland epithelium development	0.024812843215048	0.024812843215048	-1	IRF6,ZNF703,PERP,ID2,WNT7B,FGFR2
ALCOHOL METABOLIC PROCESS%GOBP%GO:0006066	alcohol metabolic process	0.024812843215048	0.024812843215048	-1	ALDH3B2,AKR1C2,SULT2B1,SPTSSB,ITPKB,HMGCS1,DEGS2,ACSS1,PLPP3,HSD11B2,ASAH1,GDPD1,AKR1C3,SPTSSA,GDPD3,SQLE,SULT1A1,CYP27B1,ACER2,NUDT4,SGPP1,HSD17B6,HMGCR,SULT1A2
DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260910%WP2291%HOMO SAPIENS	Deregulation of Rab and Rab effector genes in bladder cancer	0.024812843215048	0.024812843215048	-1	RAB27B,EXPH5,SYTL2,SYTL1,MLPH
POSITIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048639	positive regulation of developmental growth	0.024812843215048	0.024812843215048	-1	AGR2,DSCAM,SEMA5A,SYT17,CD36,SYT1,JUP,CDKL5,UNC13A,EDN1,AKAP6,FGFR2,RASAL1
VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4	Vitamin B2 (riboflavin) metabolism	0.024812843215048	0.024812843215048	-1	SLC52A3,ENPP1,ACP5,SLC52A1
REGULATION OF BLOOD-BRAIN BARRIER PERMEABILITY%GOBP%GO:1905603	regulation of blood-brain barrier permeability	0.024812843215048	0.024812843215048	-1	TJP3,ANGPT1,OCLN,TJP2
5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372	5-Hydroxytryptamine degredation	0.024812843215048	0.024812843215048	-1	ALDH3B2,MAOB,MAOA,ALDH1L1,ALDH3A1,ALDH7A1
SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7	Sphingolipid metabolism	0.024812843215048	0.024812843215048	-1	ALDH3B2,SPTSSB,ABCG2,SMPD3,DEGS2,PPM1L,PLPP3,ASAH1,SPTSSA,GALC,ARSK,CERS6,ACER2,STS,SGPP1
REGULATION OF EPIDERMIS DEVELOPMENT%GOBP%GO:0045682	regulation of epidermis development	0.024812843215048	0.024812843215048	-1	ESRP1,PKP1,SULT2B1,KDF1,ABCA12,PRKCH,BMP4,CYP27B1,SGPP1,KRT10
SENSORY ORGAN DEVELOPMENT%GOBP%GO:0007423	sensory organ development	0.024812843215048	0.024812843215048	-1	SHROOM2,SOX2,PBX1,FREM2,DSCAM,SGCG,MAFB,MYO6,GATA3,PAX5,CPAMD8,OSR2,ADGRV1,IFT122,FZD4,RARG,ASCL2,DRD2,KRT12,SIPA1L3,TFAP2B,TH,WNT7B,SSPN,SDK1,NECTIN1,FGFR2,SOX4,MEIS1,PITX2
HINDLIMB MORPHOGENESIS%GOBP%GO:0035137	hindlimb morphogenesis	0.024812843215048	0.024812843215048	-1	AFF3,OSR2,RARG,TFAP2B
RESPONSE TO KETONE%GOBP%GO:1901654	response to ketone	0.0259870394416664	0.0259870394416664	-1	AR,AKR1C2,TGFB3,ADCY6,TRERF1,ABCB4,SCNN1A,AKR1C3,CCR7,AHR,GOLPH3,SCNN1G
FATTY ACID DERIVATIVE BIOSYNTHETIC PROCESS%GOBP%GO:1901570	fatty acid derivative biosynthetic process	0.0259870394416664	0.0259870394416664	-1	ALOX15,ACSS3,GGT6,FAR2,ELOVL5,ACSL3,HMGCS2,SLC27A2,HMGCLL1,ACSL1
DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625	Defective GALNT3 causes HFTC	0.0273589218926985	0.0273589218926985	-1	MUC1,GALNT3,MUCL1,MUC20,MUC15,MUC16
WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057	Wnt signaling pathway	0.0273589218926985	0.0273589218926985	-1	CDH1,CDH12,CDH18,LEF1,PRKCH,FZD4,PCDHB5,PCDHA13,PCDHA3,PCDHA6,PCDH19,NFATC4,PCDH1,CDH13,PCDH8,PCDHGA3,PCDHA1,WNT7B,PCDHA9,CDH3,PCDHGA8,TLE6,ARRB1,TLE2,PCDHA12,PCDHB13
REGULATION OF CELL PROJECTION ORGANIZATION%GOBP%GO:0031344	regulation of cell projection organization	0.0273589218926985	0.0273589218926985	-1	PROM2,TENM1,TACSTD2,DSCAM,TGFB3,ADCY6,FUT9,SEMA5A,EPHA3,MYLIP,NEDD9,FAM110C,TRIM46,PLA2G3,KIF13B,MAP6,CDC42EP5,DCDC2,FZD4,LIMA1,ARHGAP32,SIPA1L1,SRCIN1,JUP,CDKL5,EPS8L1,EPHB3,HECW2,SH3YL1,CCR7,OCLN,SYNE1,SYNE2,NTRK2,RABL3,MBOAT1,RAP1GAP,PACSIN1,SCARB2,ROBO1,CARMIL1,PTK6
HOMOPHILIC CELL-CELL ADHESION%GOBP%GO:0007156	homophilic cell-cell adhesion	0.0273589218926985	0.0273589218926985	-1	CDH1,NECTIN4,CLSTN2,DSCAM,MPZL2,IGSF9,HMCN1,AMIGO2,CDH13,SDK1,NECTIN1,ROBO1
PROTEIN LOCALIZATION TO CELL-CELL JUNCTION%GOBP%GO:0150105	protein localization to cell-cell junction	0.0273589218926985	0.0273589218926985	-1	ANK3,TJP3,MPP7,ILDR1,CGNL1,TJP2
METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260910%WP702%HOMO SAPIENS	Metapathway biotransformation Phase I and II	0.0273589218926985	0.0273589218926985	-1	CYP2J2,HS6ST3,AKR1C2,CYP4Z1,SULT2B1,FMO4,CYP4F8,CYP4F22,CYP4F3,MGST1,MGST2,CYP4F12,UGT2B15,HS3ST5,FMO5,CYP4X1,SULT1A1,CYP27B1,SULT1A2
PROTEIN LOCALIZATION TO CELL JUNCTION%GOBP%GO:1902414	protein localization to cell junction	0.0275039242617354	0.0275039242617354	-1	ANK3,NRXN3,MARVELD3,TJP3,MPP7,RAB27B,ILDR1,DLG3,CGNL1,NECTIN1,TJP2
CELLULAR RESPONSE TO KETONE%GOBP%GO:1901655	cellular response to ketone	0.0275039242617354	0.0275039242617354	-1	AR,AKR1C2,ADCY6,TRERF1,SCNN1A,AKR1C3,CCR7,AHR,GOLPH3,SCNN1G
SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470	sphingosine and sphingosine-1-phosphate metabolism	0.0305409371516864	0.0305409371516864	-1	ASAH1,SLC27A2,ACER2,SGPP1,ACSL1
NEURON PROJECTION MORPHOGENESIS%GOBP%GO:0048812	neuron projection morphogenesis	0.0330343606853229	0.0330343606853229	-1	ANK3,ALCAM,TENM1,NRXN3,NOTCH3,SLITRK6,DSCAM,UNC5C,IGSF9,CTNND2,SEMA5A,EPHA3,TRIM46,FLRT3,MAP6,NTN4,SEMA4A,DRD2,NRCAM,SEMA3F,EPHB3,POTEI,RPS6KA5,POTEF,ATP7A,NCAM1,EPHA6,WNT7B,POTEE,FGFR2,PACSIN1,ROBO1
EPIDERMAL CELL DIFFERENTIATION%GOBP%GO:0009913	epidermal cell differentiation	0.0330343606853229	0.0330343606853229	-1	GRHL2,OVOL1,CSTA,MYO6,ST14,POU2F3,ABCA12,OVOL2,SPINK5,EXPH5,ASAH1,AKR1C3,CDH3,KRT10,PITX2
SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.0330343606853229	0.0330343606853229	-1	ALOX15,CYP4B1,CYP4F8,CYP4F22,CYP4F3,CYP4A22
CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION%GOBP%GO:0048667	cell morphogenesis involved in neuron differentiation	0.0330343606853229	0.0330343606853229	-1	ANK3,ALCAM,TENM1,NRXN3,NOTCH3,SLITRK6,DSCAM,UNC5C,IGSF9,CTNND2,SEMA5A,EPHA3,TRIM46,MAP6,NTN4,SEMA4A,DRD2,NRCAM,SEMA3F,EPHB3,POTEI,RPS6KA5,POTEF,NCAM1,EPHA6,WNT7B,POTEE,FGFR2,ROBO1
HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM	HALLMARK_XENOBIOTIC_METABOLISM%MSigdbHallmark%HALLMARK_XENOBIOTIC_METABOLISM	0.0331922719695398	0.0331922719695398	-1	KYNU,CYP2J2,AKR1C2,CD36,ARG2,MAOA,GCNT2,IL1R1,NDRG2,JUP,ALDH3A1,MAN1A1,ELOVL5,MCCC2,DDC,RAP1GAP,CROT,SLC35D1,ENTPD5
TRIPEPTIDE TRANSPORT%GOBP%GO:0042939	tripeptide transport	0.0359397346206021	0.0359397346206021	-1	MGST1,ABCC5,SLC15A2,SLC13A3
NOREPINEPHRINE METABOLIC PROCESS%GOBP%GO:0042415	norepinephrine metabolic process	0.0359397346206021	0.0359397346206021	-1	GATA3,RNF180,TH,ATP7A
KETONE CATABOLIC PROCESS%GOBP%GO:0042182	ketone catabolic process	0.0359397346206021	0.0359397346206021	-1	CYP4F8,CYP4F3,CYP4F12,HSD17B6
HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME	HALLMARK_PEROXISOME%MSigdbHallmark%HALLMARK_PEROXISOME	0.0362711807353326	0.0362711807353326	-1	SULT2B1,ABCB4,CRABP2,HSD11B2,ELOVL5,ISOC1,ABCC5,ATXN1,HSD17B4,SLC27A2,STS,CRABP1,ACSL1
MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260910%WP2857%HOMO SAPIENS	Mesodermal commitment pathway	0.0362711807353326	0.0362711807353326	-1	FOXA1,SOX2,PBX1,GATA3,EPB41L5,LEF1,FZD4,BMP4,VAV3,TBX6,TOX3,TCF4,DNMT3B,JARID2,MEIS1,PITX2
APICAL JUNCTION ASSEMBLY%GOBP%GO:0043297	apical junction assembly	0.0362711807353326	0.0362711807353326	-1	GRHL2,MARVELD3,POF1B,MPP7,MARVELD2,CLDN1,SLC39A9,OCLN
PLASMA MEMBRANE BOUNDED CELL PROJECTION MORPHOGENESIS%GOBP%GO:0120039	plasma membrane bounded cell projection morphogenesis	0.0362711807353326	0.0362711807353326	-1	ANK3,ALCAM,TENM1,NRXN3,NOTCH3,SLITRK6,DSCAM,UNC5C,IGSF9,CTNND2,SEMA5A,EPHA3,TRIM46,FLRT3,MAP6,NTN4,SEMA4A,DRD2,NRCAM,SEMA3F,EPHB3,POTEI,RPS6KA5,POTEF,ATP7A,NCAM1,EPHA6,WNT7B,POTEE,FGFR2,PACSIN1,ROBO1
SULFUR COMPOUND METABOLIC PROCESS%GOBP%GO:0006790	sulfur compound metabolic process	0.0362711807353326	0.0362711807353326	-1	SULT2B1,ENPP1,GGT6,HMGCS1,MGST2,ACSS1,FAR2,CSAD,AHCYL1,ACOT4,ELOVL5,MCEE,MAT1A,ACSL3,HSD17B4,HMGCS2,SULT1A1,CROT,SLC27A2,ACOT11,THEM5,GNMT,MAT2A,ACSL1,SULT1A2
MULTICELLULAR ORGANISMAL-LEVEL HOMEOSTASIS%GOBP%GO:0048871	multicellular organismal-level homeostasis	0.0362787453074845	0.0362787453074845	-1	ANK3,MYO5B,FREM2,TJP3,TFF1,ADCY6,BPIFA4P,TFF3,ACP5,ANGPT1,SLC39A8,FREM1,OAS1,CD36,ADGRV1,CLDN1,CYP4F12,DMD,GCNT2,DRD2,PERP,SORL1,ID2,ILDR1,SCNN1A,APBB2,SLC11A2,HCAR2,MPIG6B,OCLN,AQP6,CDH3,SLC12A2,TJP2,P2RX4,SCNN1G,SERPINA3
POSITIVE REGULATION OF VASCULAR PERMEABILITY%GOBP%GO:0043117	positive regulation of vascular permeability	0.0368864456513382	0.0368864456513382	-1	TJP3,ZG16B,ANGPT1,OCLN,TJP2
REGULATION OF EPIDERMAL CELL DIFFERENTIATION%GOBP%GO:0045604	regulation of epidermal cell differentiation	0.0368864456513382	0.0368864456513382	-1	ESRP1,PKP1,SULT2B1,KDF1,ABCA12,PRKCH,BMP4,CYP27B1,SGPP1
AXON GUIDANCE%GOBP%GO:0007411	axon guidance	0.0368864456513382	0.0368864456513382	-1	ALCAM,TENM1,NRXN3,NOTCH3,DSCAM,UNC5C,IGSF9,SEMA5A,EPHA3,NTN4,SEMA4A,NRCAM,SEMA3F,EPHB3,RPS6KA5,NCAM1,EPHA6,WNT7B,ROBO1
CARBOXYLIC ACID CATABOLIC PROCESS%GOBP%GO:0046395	carboxylic acid catabolic process	0.0368864456513382	0.0368864456513382	-1	KYNU,QPRT,HGD,PRODH,CYP4F12,ALDH1L1,CSAD,DDAH1,ACOXL,NPL,ACOT4,MCEE,ALDH5A1,MAT1A,HSD17B4,ALDH6A1,MCCC2,DECR1,CROT,SLC27A2,HMGCLL1,ALDH7A1
ACYL-COA METABOLIC PROCESS%GOBP%GO:0006637	acyl-CoA metabolic process	0.0368864456513382	0.0368864456513382	-1	HMGCS1,ACSS1,FAR2,ACOT4,ELOVL5,MCEE,ACSL3,HSD17B4,HMGCS2,SLC27A2,ACOT11,THEM5,ACSL1
NEURON PROJECTION GUIDANCE%GOBP%GO:0097485	neuron projection guidance	0.0368864456513382	0.0368864456513382	-1	ALCAM,TENM1,NRXN3,NOTCH3,DSCAM,UNC5C,IGSF9,SEMA5A,EPHA3,NTN4,SEMA4A,NRCAM,SEMA3F,EPHB3,RPS6KA5,NCAM1,EPHA6,WNT7B,ROBO1
POSITIVE REGULATION OF EPIDERMIS DEVELOPMENT%GOBP%GO:0045684	positive regulation of epidermis development	0.0368864456513382	0.0368864456513382	-1	PKP1,SULT2B1,KDF1,PRKCH,BMP4,CYP27B1,KRT10
DIOL METABOLIC PROCESS%GOBP%GO:0034311	diol metabolic process	0.0368864456513382	0.0368864456513382	-1	SPTSSB,DEGS2,PLPP3,ASAH1,SPTSSA,ACER2,SGPP1
SPHINGOSINE METABOLIC PROCESS%GOBP%GO:0006670	sphingosine metabolic process	0.0368864456513382	0.0368864456513382	-1	SPTSSB,PLPP3,ASAH1,SPTSSA,ACER2,SGPP1
REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048638	regulation of developmental growth	0.0387513488650355	0.0387513488650355	-1	AGR2,LIN7A,DSCAM,SEMA5A,SYT17,TRIM46,CD36,WWC3,SYT1,CDKN1B,JUP,CDKL5,NRCAM,UNC13A,EDN1,AKAP6,FGFR2,RASAL1
CELL PROJECTION MORPHOGENESIS%GOBP%GO:0048858	cell projection morphogenesis	0.0388283545813261	0.0388283545813261	-1	ANK3,ALCAM,TENM1,NRXN3,NOTCH3,SLITRK6,DSCAM,UNC5C,IGSF9,CTNND2,SEMA5A,EPHA3,TRIM46,FLRT3,MAP6,NTN4,SEMA4A,DRD2,NRCAM,SEMA3F,EPHB3,POTEI,RPS6KA5,POTEF,ATP7A,NCAM1,EPHA6,WNT7B,POTEE,FGFR2,PACSIN1,ROBO1
HEART CONTRACTION%GOBP%GO:0060047	heart contraction	0.0402051106764889	0.0402051106764889	-1	KCNJ3,CACNA1D,SGCG,SCN2A,TNNI1,KCNE4,CAMK2D,DMD,FGF12,RYR2,ANK2,TNNT2
CARDIAC MUSCLE CONTRACTION%GOBP%GO:0060048	cardiac muscle contraction	0.0439368548387088	0.0439368548387088	-1	KCNJ3,CACNA1D,SCN2A,TNNI1,KCNE4,CAMK2D,DMD,FGF12,RYR2,ANK2,TNNT2
CELL SURFACE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY%GOBP%GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	0.0439368548387088	0.0439368548387088	-1	PIK3R3,GALNT3,REPS2,EPHA3,NEDD9,ANGPT1,GRB14,FLRT3,TGFA,FRK,SULF1,PRLR,SORBS1,EPHA1,MUC20,NFATC4,MTSS1,SIPA1L1,FOXO4,COL4A6,EPHB3,DDR1,ERBB2,EPHA6,NTRK2,SAMD12,GAB1,GAREM1,FGFR2,ARHGEF28,ANKS1B,PTK6
EYE DEVELOPMENT%GOBP%GO:0001654	eye development	0.0444375911443763	0.0444375911443763	-1	SHROOM2,SOX2,PBX1,FREM2,DSCAM,SGCG,CPAMD8,OSR2,IFT122,FZD4,RARG,DRD2,KRT12,SIPA1L3,TFAP2B,TH,WNT7B,SSPN,SDK1,SOX4,MEIS1,PITX2
CELLULAR RESPONSE TO ALCOHOL%GOBP%GO:0097306	cellular response to alcohol	0.0453965937491731	0.0453965937491731	-1	CDH1,AKR1C2,ADCY6,JUP,SCNN1A,AKR1C3,CCR7,AHR,GOLPH3,SCNN1G
REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010810	regulation of cell-substrate adhesion	0.0453965937491731	0.0453965937491731	-1	AGR2,ALOX15,NPNT,TACSTD2,EPHA3,NEDD9,EMP2,LEF1,CDK6,CD36,CCL28,FZD4,GCNT2,EPHA1,PLPP3,JUP,CDH13,CCR7,ACER2,CARMIL1
CARDIAC MUSCLE CELL ACTION POTENTIAL%GOBP%GO:0086001	cardiac muscle cell action potential	0.0453965937491731	0.0453965937491731	-1	ANK3,KCNJ3,CACNA1D,SCN2A,KCNE4,CAMK2D,DMD,FGF12,RYR2,ANK2
REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010717	regulation of epithelial to mesenchymal transition	0.0454017330119138	0.0454017330119138	-1	FOXA1,BAMBI,TGFB3,GATA3,EPHA3,EMP2,LEF1,ZNF703,OVOL2,LDLRAD4,GCNT2,LRG1,ZNF750
DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995	Diseases associated with O-glycosylation of proteins	0.0465412984957288	0.0465412984957288	-1	ADAMTS19,ADAMTS1,NOTCH3,MUC1,GALNT3,MUCL1,SEMA5A,MUC20,MUC15,MUC16,LARGE1
HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260910%WP2840%HOMO SAPIENS	Hair follicle development cytodifferentiation stage 3 of 3	0.0465412984957288	0.0465412984957288	-1	SOX2,GATA3,IGFBP5,LEF1,KITLG,BMP4,TP63,SPINK5,PERP,KRT19,TCF4,DLX3