NCI-H1339, NCI-H157, and NCI-H1264 are reported to come from different donors but have matching STR profiles (Yu et al, 2015). ICLAC made contact with the originator's laboratory to discuss the match. They have fresh stocks of NCI-H1339 with the correct fingerprint matching NCI-BL1339, which is a lymphoblastoid cell line from the same donor. (ICLAC v9)
The origin of KMS-21-BM is unclear. The line was though to originate from the same patient as KMS-21-PE however STR profiling has showed this to be incorrect. The true donor infomration for both lines is consequently uncertain. (JCRB, ICLAC)
Derived through sequential passaging in nude mice of cell line COLO-357.
The RH-18 cell line was generated from a xenograft derived from a tumor from a previously untreated 2-year-old patient with a perineal RMS assigned as embryonal histology. (PMID: 23882450).
SW626 may have been derived from an ovarian metastasis of a primary adenocarcinoma of the colon (ATCC).
Allegedly established from the peripheral blood of a 40-year-old man with acute monoblastic leukemia (AML M5) at relapse in 1982 ; however, recent new data suggest derivation from acute lymphoblastic leukemia based on the expression signature (Andersson et al., Leukemia 19: 1042-1050, 2005, DSMZ).
Prostate epithelial cells from a 68-year-old man with benign prostate hyperplasia cells were immortalized with SV-40 large T-antigen (DSMZ).
The human umbilical vein cell line, EA.hy926, was established by fusing primary human umbilical vein cells with a thioguanine-resistant clone of A549 by exposure to polyethylene glycol (PEG). Hybrid clones were selected in HAT medium and screened for factor VIII-related antigen. (ATCC)
Originally thought to be a Hodgkin's cell line but is a B-lymphoblastoid cell line (PMID: 12592342, Sanger).
Misidentified, now shown to be a B-cell lymphoma and not from a gastric cancer (PMID: 12226758).
Misidentified, now shown to be a B-cell lymphoma and not from a gastric cancer (PMID: 12226758).
https://www.austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1055.php
https://www.austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1055.php
https://www.austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1055.php
https://www.austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1055.php
https://www.austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1055.php
https://www.austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v2-id1055.php
The RH-28 cell line was derived from a xenograft of tumor tissue obtained from an axillary node metastasis in a previously untreated 17-year-old male. (PMID: 23882450).
Epstein-Barr virus (EBV) immortalized.
http://cancerres.aacrjournals.org/content/68/9_Supplement/3743
SUM229PE was established by Stephen Ethier and distributed by Asterand (later acquired by BioIVT).  ICLAC was notified that the STR profile in Asterand's Certificate of Analysis matched SUM149PT.  Stephen Ethier was contacted to ask about this finding and confirmed that SUM229PE and SUM149PT were established from different donors.  An updated Certificate of Analysis was then issued; looking at the STR profile, the problem appears to have been corrected.  The correct STR profile is available on Cellosaurus. (ICLAC v9)
http://cancerres.aacrjournals.org/content/68/9_Supplement/3743
Suspected to be a  B-lymphoblastoid cell line rather than a bona fide B-CLL cell line (DSMZ, PMID: 12592342).
Potentially mis-identified: Grand-parent cell line (GM01500) was originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line. (Cellosaurus)
Epstein-Barr virus (EBV) immortalized.
A variant of HuG1 producing hybrid type of alkaline phosphatase.
Patient has a history of asbestos exposure.
Note made of patient's history of exposure to asbestos (ECACC).
Model reference: https://ci.nii.ac.jp/naid/110002117678/en
Development of cancer within the patient linked to an infection with Opisthorchis viverrini (DOI: 10.1016/j.ijpara.2010.05.002)
RBE and SSP-25 were originally reported to have been derived from the same patient. However, their STR profiles indicate that these cell lines come from different individuals (RIKEN).
Note made of patient's history of exposure to asbestos (ECACC).
RCC4-VHL was established from RCC4 by stable transfection with the vector, pcDNA3-VHL, conferring neomycin resistance and encoding the von Hippel-Lindau (VHL) tumour suppressor gene product pVHL (ECACC).
Resistant to 10nM of gemcitabine (DOI: 10.1007/s00534-011-0376-7).
SF8657 is a finite cell line of fibroblasts established from a skin biopsy of a non-exposed individual with stomach cancer.
Note made of patient's history of exposure to asbestos (ECACC).
Note made of patient's history of exposure to asbestos (ECACC).
Note made of patient's history of exposure to asbestos (ECACC).
Note made of patient's history of exposure to asbestos (ECACC).
Adapted for growth in serum free media.
The RCC4-emptyvector cell line was established from RCC4 by stable transfection with an empty expression vector, pcDNA3, conferring neomycin resistance (ECACC).
Dabrafenib and Trametinib resistant subclone of A375.
SCH772984 resistant subclone of A375.
Dabrafenib and Trametinib resistant subclone of A375.
ARH-77 is a B-lymphoblastoid cell line (PMID: 12592342).
The cells were immortalized by transduction with human papilloma virus 16 (HPV-16) E6/E7 genes (ATCC).
Telomerase (TERT) immortalised (Cellosaurus).
Although derived from the blood of a patient with multiple myeloma this line has been shown to be an EBV-transformed B lymphoblastoid cell line (ATCC).
A variant of HuG1 producing Nagao-type alkaline phosphatase.
https://www.nature.com/articles/301429a0.pdf
Suspected mis-identification. Originally thought to be a high grade ovarian serous adenocarcinoma but suspected to have a upper gastrointestinal origin (DOI: 10.1093/nar/gkw578).
Originally thought to be of human origin but found to be from mouse (PMID: 20143388, Cellosaurus).
Cell line was derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft (DSMZ).
PWR-1-E was single cell clone isolated from cells derived from non-neoplastic adult human prostate cells that were infected with the Ad12-SV40 virus (PMID: 8761420).
RPMI-6666 was initially thought to have been derived from Hodgkin lymphoma, but is now known to be an EBV-positive B-lymphoblastoid cell line (PMID: 12592342).
Treated by transcatheter arterial embolization with lipoidol plus doxorubicin.
Expression profile suggests origin is Ewings Sarcoma (DOI: 10.1002/pbc.21099).
Note made of patient's history of exposure to asbestos (ECACC).
Resistant to 100nM of gemcitabine (DOI: 10.1007/s00534-011-0376-7).
Leukaemic cell byproduct of a therapeutic pheresis of a patient with M5a AML (PMID: 12437665)
Established from a xenotransplanted choriocarcinoma grown in nude mice.
CLPUB00051: https://www.cellosaurus.org/cellopub/CLPUB00051
CLPUB00051: https://www.cellosaurus.org/cellopub/CLPUB00051
Cells carry the Philadelphia chromosome with an e13-a2 (b2-a2) BCR-ABL1 fusion gene and an inv(3) leading to MECOM (EVI1) overexpression (DSMZ).
Patient had known exposure to crocidolite asbestos.
Patient had known exposure to crocidolite asbestos.
Patient had known exposure to crocidolite asbestos.