Dataset | ranked_basal_vs_classical
Phenotype | NoPhenotypeAvailable
Upregulated in class | na_neg
GeneSet | ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS
Enrichment Score (ES) | -0.85529995
Normalized Enrichment Score (NES) | -1.8855408
Nominal p-value | 0.0
FDR q-value | 0.010700012
FWER p-Value | 0.252
Table: GSEA Results Summary

Fig 1: Enrichment plot: ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT
1 | UGT1A10 | 2892 | 1.329 | -0.1393 | No
2 | CYP1B1 | 5795 | 0.396 | -0.2941 | No
3 | UGT1A8 | 7288 | 0.171 | -0.3742 | No
4 | HSD17B1 | 10134 | -0.130 | -0.5300 | No
5 | SULT1E1 | 11128 | -0.264 | -0.5809 | No
6 | HSD17B10 | 12727 | -0.577 | -0.6604 | No
7 | HSD17B4 | 16222 | -2.325 | -0.8172 | Yes
8 | HSD17B3 | 16909 | -3.478 | -0.7997 | Yes
9 | HSD17B7 | 17091 | -3.884 | -0.7477 | Yes
10 | CYP2C8 | 17160 | -4.113 | -0.6857 | Yes
11 | UGT2B7 | 17333 | -4.728 | -0.6197 | Yes
12 | CYP2C19 | 17507 | -5.600 | -0.5398 | Yes
13 | CYP2C9 | 17616 | -6.352 | -0.4443 | Yes
14 | CYP3A4 | 17811 | -8.382 | -0.3211 | Yes
15 | HSD17B2 | 17870 | -9.595 | -0.1710 | Yes
16 | CYP3A7 | 17937 | -11.246 | 0.0051 | Yes
Table: GSEA details [plain text format]

Fig 2: ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS: Random ES distribution
Gene set null distribution of ES for ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS