Informatics for RNA-Seq Analysis 2019

Welcome

Welcome to Informatics for RNA-Seq Analysis 2019.

The course schedule can be found here.

Meet your faculty here

We are using Slack for discussion. Join the Slack channel.

CLASS MATERIALS: The full course notes are available as a single PDF.

Pre-Workshop Preparation

Laptop Setup Instructions

Instructions to setup your laptop can be found here.

Pre-workshop Tutorials

Pre-readings and pre-work can be found here here.
It is in your best interest to complete these before the workshop.


Class Photo

Class Photo


Day 1

Day 1 and Day 2 refer to content on rnabio.org.

Welcome

Michelle Brazas

Module 1: Introduction to Cloud Computing

Malachi Griffith

Lecture

Updated Lecture on Connecting to AWS

Lab Practical: Connecting to the Cloud

  • We have set up instances on the Amazon cloud - one for each student. In order to log in to your instance, you will need a security certificate. The certificates will be uploaded to Slack. If you plan on using Linux or Mac OS X, Please use CBWRNA.pem; Otherwise if you plan on using Windows (with Putty), please use CBWRNA.ppk.

You can also download from here. Mac/Linux certificate, Windows certificate.

Module 2: Introduction to RNA Sequencing Analysis

Malachi Griffith

Lecture

Module 2 Lab Practical

Installation

Reference Genomes

Annotations

Indexing

Data

Data QC

Module 3: RNA-seq Alignment and Visualization

Malachi Griffith

Lecture

Module 3: RNA-seq Alignment and Visualization Lab Practical

Malachi Griffith

Adapter Trim

Alignment

IGV

Alignment Visualization

Alignment QC

Integrated Assignment

Megan Richters and Kelsy Cotto

Assignment Questions

Assignment Answers


Day 2

Module 4: Expression and Differential Expression

Obi Griffith

Lecture

Updated Lecture 4-PartA
Updated Lecture 4-PartB
Updated Lecture 4-PartC

Module 4 Lab

Expression

Differential Expression

DE Visualization

Module 5: Reference Free Alignment

Obi Griffith

Lecture

Kallisto

Module 6: Isoform Discovery and Alternative Expression

Obi Griffith

Lecture

Integrated Assignment

Assignment Questions

Assignment Answers

Keeping Up-to-date with RNA-Seq Analysis Developments

For additional resources, tutorials, future directions, and more please refer to the RNA-seq wiki


Day 3

Module 7: Genome Guided and Genome-Free Transcriptome Assembly

Brian Haas

Lecture

Bandage

Lab practical

Module 8: Functional Annotation and Analysis of Transcripts

Brian Haas

Lecture

Lab practical

Post Workshop

Post workshop content for data sets, AWS image, tools and install instructions can be found here


Additional Optional Resources

Lecture on Single Cell Seq

Additional resources can be found on the RNA-Seq wiki.


Thank you for attending the Informatics for RNA-Seq Analysis workshop! Help us make this workshop better by filling out our survey